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--- content:methylphenidate [2024/03/22 21:12] – [Table] biju.hameed@gmail.com
+++ content:methylphenidate [2024/03/22 21:25] (current) – [Methylphenidate Preparations] biju.hameed@gmail.com
@@ Line 1: / Line 1: @@
 ====== Methylphenidate Preparations ======
-Methylphenidate is available in 2 different isomer formulations. It is essential to know which formulation you are dealing with when converting from 1 stimulant to another. Those conversions are less precise if the new medication has a different formulation of isomers than the old one.
+Methylphenidate (MPH) is available in 2 different isomer formulations. It is essential to know which formulation you are dealing with when converting from one stimulant to another. Those conversions are less precise if the new medication has a different formulation of isomers than the old one.
   * 50% Dex and 50% Levomethylphenidate
     * Ritalin, Methylin, Ritalin SR, Methylin ER, Metadate ER,Ritalin LA, Metadate CD, Aptensio XR, Adhansia XR, Concerta, QuilliChew ER, Quillivant XR, Cotempla XR-ODT, Daytrana, Jornay PM, Medikinet
   * 100% dexmethylphenidate
     * Focalin, Focalin XR
-^ Methylphenidate                                                 ^ Duration (hr)  ^
 | METHYLPHENIDATE                                                 | DURATION (HRS)  |
 | Ritalin, Methylin                                               | 3-5             |
@@ Line 15: / Line 15: @@
 | Concerta, Aptensio XR,Quillivant XR, Daytrana, Cotempla XR-ODT  | 12              |
 | Adhansia XR                                                     | 16              |
-| Dexmethylphenidate  (Focalin)                                   |  3-5            |
+| Dexmethylphenidate  (Focalin)                                   | 3-5            |
 | Dexmethylphenidate XR (Focalin XR)                              | 8-12            |
-  * The stimulants also vary in their duration of action, from 3-5 hours with Ritalin to 16 hours with Adhansia and Mydayis. If you are switching to a stimulant with a longer duration of action, you may need to raise the dose because it will be spread out over a longer period of time.
+  * The stimulants also vary in their duration of action, from 3-5 hours with Ritalin to 16 hours with Adhansia and Mydayis.
+  * If you are switching to a stimulant with a longer duration of action, you may need to raise the dose because it will be spread out over a longer period of time.
 ==== Switching to or from stimulants with unique absorptions and bioavailability ====
 such as orally disentegrating ODTs (Adzenys, Cotempla), transdermal Daytrana, or delayed-release Jornay PM
   * If the new stimulant has the same bioavailability and isomer as the old one, the conversion is complete
   * Evekeo ODT has the same bioavailability as regular Evekeo and requires no adjustment
-^ Cotempla ODT-XR        ^ Jornay PM               | Adzenys ODT      |
+| <fc #4682b4>**Cotempla ODT-XR**</fc>        | <fc #4682b4>**Jornay PM**</fc>               | <fc #4682b4>**Adzenys ODT**</fc>      |
 | Methylphenidate x0.86  | Methylphenidate x 1.35  | Adderall x 0.63  |
-^ Concerta        ^  Ritalin LA or Metadate CD  | Daytrana              |
+^ **Concerta**   ^  **Ritalin LA** or **Metadate CD**  | **Daytrana**          |
-| 18 mg/day       | 10-20 mg/d                  | 10 mg/9 hr wear time  |
+| 18 mg/day      | 10-20 mg/d                          | 10 mg/9 hr wear time  |
-| 27 mg/day       | 30 mg/day                   | 15 mg/9 hr wear time  |
+| 27 mg/day      | 30 mg/day                           | 15 mg/9 hr wear time  |
-|  36 mg/day      | 40 mg/day                   | 20 mg/9 hr wear time  |
+| 36 mg/day      | 40 mg/day                           | 20 mg/9 hr wear time  |
-| 54 mg/day       | 50 mg/day                   | 30 mg/9 hr wear time  |
+| 54 mg/day      | 50 mg/day                           | 30 mg/9 hr wear time  |
+==== Isomer Adjustments ====
+  * All conversions are approximate,particularly when converting among different isomer mixes.
+  * For methylphenidate, most of the potency is due to it's dexIsomer, so you can convert from methylphenidate (which is 50%dex) to dexmethy|phenidate (100% dex) by cutting the dose in half.
+==== Medikinet® retard and Concerta® ====
 Medikinet® retard and Concerta® are two MPH preparations with different release profiles and proved efficacy on ADHD symptoms as well as co-morbid conditions.
-==== Medikinet ====
+**Medikinet**
   * Medikinet retard contains equal proportions of IR and slow release MPH. This once-daily extended-release formulation had a duration of action of about 8 hours in an analog classroom setting.
@@ Line 40: / Line 50: @@
   * Medikinet XL may, therefore, be administered either as an intact capsule, or the capsule may be opened and the contents swallowed, without chewing, immediately after sprinkling onto applesauce or other similar soft food.
-==== Concerta ====
+**Concerta**
   * The tablet coating of Concerta dissolves within 1 to 2 hours and releases 22% of the total dose of MPH providing an initial maximum drug concentration at about 1 to 2 hours.