Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. Researchers have now identified a gene, called HLA-A*3101, in Caucasian patients that increases the risk of developing a reaction to the drug from 5% to 26%.
Researchers at Concordia University have pioneered a computer-based method to detect epileptic seizures as they occur - a new technique that may open a window on the brain's electrical activity. Their paper, "A Novel Morphology-Based Classifier for Automatic Detection of Epileptic Seizures," presented at the annual meeting of the Engineering in Medicine and Biology Society, documents the very successful application of this new seizure-detection method.
The results of the landmark major multi-center randomized clinical trial "Management of Myelomeningocele Study (MOMS)" report on fetal surgery for spina bifida has been published in the 9 February issue of the New England Journal of Medicine, NEJM. The results indicate that prenatal surgery for spina bifida has greatly improved benefits over postnatal repair, by reducing the need for shunting and improving motor outcomes.
American Academy of Pediatrics (AAP) publishes updated practice guidelines on simple febrile seizures, in the January 31 issue of Pediatrics. Following a comprehensive review of the evidence based literature from 1996 to February 2009, the AAP have published updated guidelines on simple febrile seizures which replaces the 1996 practice statndards.