Prof. Dieter Janz [1920-2016]

Prof. Dieter Janz, Berlin, an iconic figure in the history of epileptology has passed away on December 24, 2016. He was 96 years old. Prof. Janz has made numerous contributions to the field of epileptolgy. In 1957, Janz and Walter Christian described "juvenile myoclonic epilepsy", which was later named after Janz, as a syndrome ​. Prof. Janz, among other things, drew attention to the teratogenic effects of antiepileptic drugs and was also one of the first to report the l...
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ICNA needs your support

Dear colleagues,

We are writing today to ask for your support for the International Child Neurology Association (ICNA) and its activities.  http://www.icnapedia.org

The work that ICNA performs is entirely financed from funds raised.  Membership is now free and has grown considerably to over 2,000 members since we implemented this policy in 2012.  

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Professor Brian Neville 1939-2016

It is with great sadness that we report the passing of Brian Neville, formerly Professor of Paediatric Neurology at UCL Institute of Child Health, London 1989-2004, and The Prince of Wales’s Chair of Childhood Epilepsy 2004-2007, in the early hours of 14th December 2016. He had battled ill health over a long period of time. As the first Chair of Paediatric Neurology in the UK, he set up the first academic department of Paediatric Neurology and Neurodisability at Great Ormond Street Hospital and the Institute of Child Health (later UCL-ICH). He wrote the training programmes for Paediatric Neurology for Europe...
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Diffusion tensor imaging (DTI) to locate epileptogenic abnormalities not detected by 3T MRI

(A) FA decrease in patient group with right-sided FCD. (B) FA decrease in patient group with left-sided FCD. (C) FA decrease in the analysis of patients with left and right-sided lesions altogether after flipping the MRIs with right-sided FCD lesions. The yellow/red voxel indicated brain regions where the FA was significantly reduced in patients with focal epilepsy when compared to controls. Front. Neurol., 26 July 2012 | https://doi.org/10.3389/fneur.2012.00121

In research presented at the 2016 American Epilepsy Society annual meeting in Houston University of Munich Hospital's epilepsy center and its department of neuroradiology reported on their findings from using DTI to locate epileptogenic abnormalities. The technique is already being regularly used to guide implantation of intracranial electrodes at the University of Munich. The DTI technique involves quantification of regional U-fibers to identify microstructural abnormalities in patients with cr...
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Parents of Children with Epileptic Encephalopathies Found More Likely to Carry De Novo Mosaic Mutation for Disorder Than Previously thought

Workflow for genomic capture by molecular inversion probes

Parents of children with epileptic encephalopathies are far more likely to carry a mosaic mutation than previously thought, according to an international study that was presented at 2016 annual meeting of the American Epilepsy Society in Houston. According to the abstract presented at the meeting 10 of 109 families were found to have the mosaic de novo mutation causing epileptic encephalopathies in one of the parents. This meant that additional offspring were also at increased risk of being born...
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