Handbook of Pediatric Electroencephalography by Veena Kander now on ICNApedia VLE

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Call for Proposals 2016 for "Clinical research for new therapeutic uses of already existing molecules (repurposing) in rare diseases

E-Rare-3 Call for Proposals 2016 for "Clinical research for new therapeutic uses of already existing molecules (repurposing) in rare diseases". The eighth E-Rare joint call for funding multilateral research projects on rare diseases (JTC2016) will be open on the 7 December 2015. The following 14 countries intend to participate in this call: Austria, Canada (including Quebec), France, Germany, Hungary, Israel, Italy, Latvia, Poland, Portugal, Romania, Spain, Switzerland, Turkey. The specific objective of this call is to promote the clinical and pre-clinical proof of concept for the potential application of medicinal products in rare indications either already marketed or having achieved a...
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Abnormal cell cycle gene activity may control brain overgrowth in autistic toddlers

Further underscoring the prenatal origins of Autism Spectrum Disorder (ASD), researchers at University of California, San Diego School of Medicine describe for the first time how abnormal gene activity in cell cycle networks that are known to control brain cell production may underlie abnormal early brain growth in the disorder. The findings are published online December 14 in Molecular Systems Biology. "These findings identify common genomic defects that help explain why there are abnormal numbers of brain cells in autism, why the brain grows abnormally too large or too small in some ASD toddlers and how previously reported diverse gene mutations...
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Mutations known to cause cardiac sudden death contribute to SUDEP

Douglas E. Crompton and colleagues from Northern Health in Melbourne looked at the demographic and clinical information on SUDEP cases from 2 major centers in Australia and performed whole exome sequencing to identify rare genetic variants in these patients. They compared genes with an increased prevalence of rare pathogenic variants in SUDEP patients with 2936 control exomes. The study findings were, presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia. For the present study they analysed whole exome sequences from 62 SUDEP cases. The mean age at epilepsy onset was 10.5 years, while the mean age of SUDEP was...
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Seizure detection using multiple biosignals more accurate than detection by heart rate changes alone

According to data presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia seizure detection using multiple extracerebral biosignals specifically [HR], [SpO2] and electrodermal activity [EDA] results in improved accuracy compared with heart rate alone. Using 2 commercially available wrist-worn devices, Cogan and colleagues gathered HR, arterial oxygenation (SpO2), and EDA data from 20 patients electively admitted to an epilepsy-monitoring unit. Of these patients, 11 provided HR, SpO2, and EDA data on 24 seizures during 355 hours of data collection. In all 24 of the captured seizures HR increased by 15% or more. In 20 of these seizures, an SpO2...
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Seizure detection device sensitivity comparable to video EEG

Data presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia shows that sensitivity of the Brain Sentinel™ system for detection of GTCS is comparable to epileptologists reviewing vEEG recordings. The system, which collects continuous surface electromyography (sEMG) and audio data via a device strapped to the bicep, is currently under review by the FDA. The device algorithm continuously compares recorded surface EMG signals to the baseline sample of muscle activity. (GTC seizures are signalled with sustained activation of multiple frequency bands [30 to 40 Hz, 130 to 240 Hz, 300 to 400 Hz] of EMG activity.) Quantitative review of...
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