Natalio Fejerman [1933-2018]


Natalio Fejerman, leading Argentine child neurologist and epileptologist, died on Thursday, March 29, after a short sickbed. He was 84 years old.  Natalio Fejerman was born in Buenos Aires on November 8 th , 1933. He earned his medical degree from Medical School in Buenos Aires in 1957 and started his professional training at the Children's Hospital Ricardo Gutierrez in Buenos Aires and later at Boston Children's Hospital under Prof. Cesare Lombroso. He was the head of the Department of Neu...
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Autophagy and Cell Death - Precise Mechanisms revealed

Roles of autophagy in cell death and survival
In a study published in Current Biology today, researchers from  King's College London uncovers the precise mechanisms by which autophagy leads to cell death. The  study used a  mouse model for the polyglutamine disease dentatorubral-pallidoluysian atrophy (DRPLA), progressive acquirement of an ataxic phenotype linked to severe cerebellar cellular pathology, characterized by nuclear degeneration through nucleophagy-based LaminB1 degradation and excretion.  DRPLA is caused by ...
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Hibernating ground squirrels provide clues for neuroprotection in ischemic stroke

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  In a study published in The FASEB Journal a team of NIH-funded scientists reports on a potential drug that could be protective in ischemic stroke patients.  The clue for the study came from observations in hibernating ground squirrels. In these animals there is a dramatic reduction of cerebral blood flow during hibernation, yet they emerge from their sleep without any ill effects at all.  The researchers observed that a cellular process called SUMOylation goes into overdrive in ...
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Wrist band devices show high sensitivity with low false alarm rates in detecting seizures

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New research published in Epilepsia , a journal of the International League Against Epilepsy (ILAE), indicates that wristband devices may improve the detection and characterization of seizures in patients with epilepsy. In their attempts to develop a better monitoring method, Giulia Regalia, PhD and Francesco Onorati, PhD, of Empatica Inc. in Milan, Italy and Cambridge, Massachusetts, and their colleagues examined the potential of automated, wearable systems to detect and characterize convulsive...
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Promising new experimental combination therapy in Hypoxic Ischemic Injury

Promising new experimental combination therapy in Hypoxic Ischemic Injury
In a study published in Neonatology on Oct. 13, 2017, researchers from George Washington University, Washington, DC using newborn piglet models exposed to hypoxia-ischemia studied the ffect of standard cooling therapy (therapeutic hypothermia) alone and in combination with a selective Src kinase inhibitor, PP2, that blocks a regulatory enzyme of apoptosis (cell death). PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. This stud...
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