Font Size: 

Aim: To evaluate the relationship between clinical andcranial magnetic resonance imaging findings in patients with corpus callosumabnormalities. Materials and methods: Between September 2010 - March 2012,patients with developmental corpus callosum abnormalities were included in thestudy. Corpus callosum abnormalities were classified as total agenesis, partialagenesis and callosal hypoplasia. Regarding the groups, the association betweenradiological abnormalities and clinical findings were evaluated.Results: A total of62 patients (32 female (51.6%) and30 (48.4%) male) with a mean age of 18.0±32.1 months were enrolled in thestudy. Twenty patients (32.3%) had totalagenesis, 9 patients (14.5%) had partial agenesis and 33 (53.2%) patients hadhypoplasia of the corpus callosum. Thirty five (56.7%) cases had abnormal physicalexamination, 47 (75.8%) cases had abnormal neurological examination and 42(67.7%) cases had psychomotor retardation. There were not significantdifferences among groups regarding physical examination, psychomotorretardation, seizures or microcephaly. Seizures, psychomotor retardation andneurological abnormalities were significantly more frequent in patients withassociated other radiological abnormalities. Posterior segment of the corpuscallosum was significantly thinner in patients with psychomotor retardation andthe anterior part of the corpus callosum thinner in patients with abnormalphysical examination. Patients with totalagenesis were more prone to seizures at an early age than patients with partialagenesis or hypoplasia. Conclusion: The neurologic prognosis ofpatients with corpus callosum abnormalities is poorer in patients with anassociated neuroradiological abnormality. Early development of seizures may beobserved in cases with total agenesis of corpus callosum.

Corpus callosum thickness, corpus callosum agenesis, magnetic resonance imaging, clinical findings