In study was included 104 child with epilepsy (56 boys and 48 girls) and 28 children of control group (14 boys and 14 girls). Age 5 month-17 years. Statistical analysis of calcium contant in boys and girls of control group didn't reveal any difference. Boys with epilepsy were divided into 2 groups: before 10years old (1group) and 10-17 years old (2group), in which calcium contant in hairs significantly (P=0,90) differ. Confidentional interval (P=0,90) of calcium content in 1 group was (609.9, 1219.8)ug/g and in group 2 was (507.3, 763.8)ug/g, of girls with epilepsy (643.15, 833.15)ug/g, of control group: boys (673.55, 1226.45)ug/g, girls (752.4, 1054.5)ug/g. Thus, the main value of calcium contant in children with epilepsy was higher, then in control group. Calcium contant in hairs of boys with epilepsy of group 1 was significantly higher, then in group 2, confidence  interval of differences of mean values was (28.5, 530.1) ug/g. The study of significance of differences in calcium content among boys with epilepsy and control group revealed that in group 2 with epilepsy calcium contant was significantly (P=0,95) lowe, then in control group and confidance interval was (-58.9, -570)ug/g. Significant difference (P=0,90) in calcium content was revealed among girls with epilepsy and control group - (-6.65, -323.95)ug/g. Significant difference in calcium contant among boys and girls with epilepsy not found. Conclusions. Calcium contant in hairs of boys upper age and girls with epilepsy significantly lower (P=0,95) in comparison to control group. This study underlines the role of epilepsy in calcium metabolism and need of  antiepileptic therapy choise and correction based on identified dates.