Introduction: Evaluate the perception of quality of life (QL) in children with Duchenne muscular dystrophy (DMD) and compare with age related children without dystrophy. Methods: We investigated four male children between 9 and 15 years with DMD. For control group we considered four subjects of the same sex, age and body mass index (BMI). The QL was assessed using the instrument AUQEI - Autoquestionnaire Qualité de Vie Enfant Imagé. The questionnaire is based on the perspective of the child's satisfaction, consisting of 26 questions that explore family relationships, social activities, health, bodily functions and divorce. In the statistical analysis we used the Kolmogorov-Smirnov test and paired t test, with significance level of 5%. Results: In children with DMD mean total score of QL was 53.0 points (± 7.65), cutoff point 48, with 75% positive and 25% with impaired QL. In the control group, the mean total score of QL was 55.0 points (± 2.45), cutoff point 48, therefore all children with positive QL. The perceived QL of children with and without DMD was not significant in both the total score and for the domains (p> .05). Conclusion / Discussion: The findings show that the QL of all children were considered positive and only a child with DMD was considered impaired. This study is ongoing, seeking increase of the sample and investigation.