Font Size: 

Introduction:The incidence of peripartum maternal stroke is about 34 per 100,000 deliveries and the incidence of perinatal stroke is 1/2800 to 1/5000 live-births.Since pregnancy and delivery confera highly significant increased risk for both maternal and infant strokes, thereare likely to be as yet undiscovered interactions among maternal and infantcharacteristics in the pathogenesis of both stroke subtypes. Methods:Women with peripartum stroke and their infants, and newborns with stroke and their mothers will be identified and enrolled retrospectively back as far as 2003 and prospectively at the time of the incident stroke.  Control maternal-newborn pairs will be matched by age, race, and sexAll data will be entered into a web-based database.We will analyze predictors of stroke characteristics, risk factors and discharge outcome by using multivariate logistic regression.Results: The pilot maternal newborn stroke registry at 4 international sites has formed the first collaborative network of pediatric and adult strokeneurologists, neonatologists, and obstetricians. Our progress includes developing the protocol and obtaining IRB approval, and building the data collection form and the REDcap registry module for web-based data entry. Enrollment is ongoing at 3 of the 4 sites.Conclusion:The primary outcome of this international registry is to provide novel data on the risk factors and outcomes of maternal/newborn strokes.  We will collect clinical and imaging data and blood samples for future DNA analysis and biomarker assays to further investigate the pathophysiology of maternal and newborn strokes.