To reveale the time course of Wnt3a and Wnt5a mRNA during epileptogenesis in the Kainate-induced epilepsy model and the effect of valproate acid on the genes expression. Sprague-Dawley rats were induced by kainic acid (KA) at postnatal day 30, Real-time PCR  was applied to detect the expression of Wnt3a and Wnt5a mRNA in the hippocampus at different stages of epileptogensis.  Meanwhile we investigated whether VPA could affect the expression of Wnt3a and Wnt5a mRNA during the epileptogensis. The results show that at the acute stage after kindling, Wnt5a mRNA of KA group significantly decreased compared with that of NS group (P<0.05). At the stable stage of chronic epilepsy, the expression of Wnt5a mRNA increased significantly, compared with those of the former two stages (P<0.05). At the chronic epilepsy stage, Wnt5a mRNA had a dramatic increase  compared with that at the acute stage and the initial stage of SRS, the difference has statistical significance (both P <0.05). At different stages of epileptogenesis, Wnt5a mRNA has no significant differences between KA group and KA+VPA group.  The difference of Wnt3a mRNA expression is not significant neither among the time courses nor the different groups. The conclusion is that in kainate-induced epilepsy model, Wnt5a may be involed in the epileptogenesis by the regulation of neurogenesis in hippocapus. The antiepileptic mechanism of valproate acid is not related to Wnt3a and Wnt5a in the KA model. Wnt3a has no effect on the neurogenesis and it has no relation with the epileptogensis of kainate-induced model.