Last modified: 2014-04-03
Abstract
INTRODUCTION: Neurologic impairment is a common consequence of neurologic diseases such as CNS infection.
OBJECTIVES: To describe the neurologic outcomes of a cohort of pediatric patients with CNS infections that is evident at hospital discharge and at after one year from discharge.
METHODS: A multicentre cross-sectional retrospective cohort study at six hospitals across the Philippines over a 4 year period (2007-2010) was done. Patients with clinical features of CNS infection were included. A standardized report form was used which included the demographic profile of the patients, clinical course of the patient and outcome upon discharge and one year after. For statistical analysis, percentage, frequency, univariate and multiple logistic regression analysis were used.
RESULTS: The highest (30.42%) number of cases was from the National Capital Region. Bacterial pathogens were most commonly detected. Boys outnumbered girls by 1.2 to 1. The mean age at diagnosis was 4.7 yrs. Sixty-two patients died during their hospital stay. Etiology‚ stage of illness, and neuroimaging findings correlated significantly with poor outcome. At hospital discharge, 206 (43%) had apparently made a full recovery, and 75 (15.6%) had mild, and 103 (21.5%) had moderate to severe neurologic sequelae. Of the 151 patients who had follow-up assessment, 60 (40%) had full recovery, and 91 (60%) had neurologic sequelae .
CONCLUSION. The recognition of discrete clinical profiles among Filipino patients with CNS infection will help us toward the understanding of the etiology, course and management of this complex illness in our setting.
Keywords
References
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