Objective: During the 1^st year of life  epilepsy is most frequent in childhood. The epileptic seizures in very young infants may be severe and drug resistant. The aim of the study is to estimate epilepsy treatment results in epilepsy started during the 1^st year of life. Material and methods: 134 infants ( 60 female, 84 male,4 premature) treated in 2010-2013. All infants have video-electroencephalography, magnetic resonance imaging, metabolic  examinations  and some of them also genetic tests. Results: Structural-metabolic cases are established in 39(29.1%)infants with tuberous sclerosis complex, congenital cytomegalovirus, toxoplasmosis, hypoxic-ischemic encephalopathy, stroke, brain malformations and tumor, isobutyric acidosis. Chromosomopties were stated in 4(2.98%) and Dravet syndrome in 2(1.49%) patients.  The diagnosis of the West syndrome was established in 12(8.9) patients. Only in 2 infants benign myoclonic epilepsy in infancy was diagnosed. Antiepilepctic drug (AED)  monotherapy ( most frequently with valproic acid) was effective only in 18 (13.4%) patients. 3 infants were seizure-free on vigabatrin and 2 on levetiracetam monotherapy. In  83 (61.9%)patients treatment with 2 antiepileptic drug was effective, but 25(18.6%) required adrenocorticotropin regimen. Only in 3 infants 3 AED were used. The antiepileptic drug monotherapy was significantly less frequent                                        ( p<0.05).Conclusions: 1.Antiepileptic monotherapy is very rare effective in epilepsy started during the first year of life.2. In early onset epileptic seizures etiological factor is frequently unknown.