Last modified: 2014-04-03
Abstract
Background:Down syndrome is the most common genetic cause of mental retardation and it is estimated that 5-13 % of persons affected with Down syndrome have seizures. In one series of 350 children with Down syndrome, seizures occurred in almost 8 % and one-third was infantile spasm. Seizures evolution and EEG findings in Down syndrome haven’t been well investigated and studied.
Objectives:
- To review the experience of Hospital for Sick Children on Down syndrome patients with seizure disorder over the last 20 years.
- To follow and study the seizures’ evolution (clinically and EEG) and responding to pharmacological treatment.
Methods:
- A retrospective analysis of HSC’s data including clinical information and EEGs result collected from 1990 to 2012 for Down syndrome patients with seizure.
- All patients with Down's syndrome whose have MRI, EEG or presenting to ED or neurology clinic with seizures.
Hypothesis:
Down syndrome patients with hypsarrhythmia would present with worse cognitive outcomes
Result:
- Total number of Down Syndrome patients with seizures seen at HSC between 1990 until 2012 was 71.
- 34 out of the 71 DS patients had infantile spasm (47 % ) and 37 had other seizures type ( 53 % ).
- Out of the 34 DS with infantile spasms; 23 patients had Hypsarrhythmia and 11 had no Hypsarrythmia.
- 7 patients out of the 23 patients had sever developmental delay.
Conclusion:
Severe developmental outcomes tend to be more prevalent in Down syndrome patients with hypsarrhythmia than those Down syndrome patients without hypsarrhythmia.
Keywords
References
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