Technological advances in neonatology have provided increased survival of infants at high risk , a fact that reflects a greater number of children with neurodevelopmental disorders . The vulnerability , the risk of mortality and incidence of sequelae resulting from the conditions of birth are awakening to the need for early intervention . Objective: To assess the neurodevelopment of infants who are accompanied by a multidisciplinary team and the correlation of factors such as weight , gestational age and Apgar score in the fifth minute psychomotor development of infants at high risk. Methods : The study by reviewing medical records of infants considered at high risk were referred from the neonatal ICU of the University Hospital of Taubaté with multidisciplinary outpatient services , with more than a 1- year follow-up , receiving quarterly pacing therapies and neurological assessments . Results: 140 newborns were analyzed, 54 % were male , who presented some risk for the development of neurological disorders . Prematurity ( gestational age < 371/7 weeks) and low birth weight ( weight < 2500gr ) were the main risk factors ( p < 0.05 ) . Among the study population , 82.9 % had normal psychomotor development. Conclusion : The main factors for onset of neurological disorders are related to weight and gestational age at birth . The multidisciplinary follow up with early stimulation of infants at high risk is essential for reducing deficits in neurological development.