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Introduction: Reliable early predictors of statusepilepticus (SE)-associated mortality and morbidity are not well known in children. Methods: We conducted a prospective multicenter studyof clinical findings and laboratory data acquired at SE onset, and assessedoutcomes at the last follow-up examination. In-hospital death during the acuteperiod and neurological sequelae were classified as poor outcomes. Results: Of the 201 children who experienced theirfirst SE episode, 16 exhibited poor outcomes. Univariateanalysis revealed that the following were associated with poor outcomes: youngage (≤24 months); need for mechanical ventilation; seizure duration >90 min;seizure intractability; biphasic seizures; Glasgow Coma Scale (GCS) score<13 at 12 h after SE onset; abnormal blood glucose levels; serum aspartateaminotransferase (AST) ≥56 U/L; and C-reactive protein (CRP) levels>2.00 mg/dL. On the other hand, multivariate analysis revealed that GCSscore <13 at 12 h after SE onset and age ≤24 months werestatistically significant. To examine the earliest predictors of poor outcomewhen SE was first treated, we reanalyzed the parameters after exclusion of theGCS score. Age ≤24 months, AST levels ≥56 U/L, and CRP levels >2.00 mg/dL weredetermined to be statistically significant. Conclusions: Prolonged unconsciousness and young age werehighly predictive of poor outcomes in pediatric patients with SE. Moreover,elevated AST and CRP levels were predictors that might be closely associatedwith the etiology of SE in Japanese children.

Status epilepticus; Prognosis; Predictor