Landau-Kleffner Syndrome (LKS), is an epileptic disorder characterized by acquired aphasia and auditory agnosia, focal/multifocal spikes and spikes-waves over the temporal region. In 70-80% of the cases epileptic seizures may occur. There are no controlled clinical trials that have investigated treatment in LKS. We describe three-year follow-up of four cases of LKS in  4 to 7 years old children, who improved after a 400 mg/kg /day dose of intavenous immunoglobulin (IVIG) for five consecutive days, after various antiepileptic therapy had failed. In conclusion, IVIG therapy should be considered in cases of LKS who did not respond to traditional antiepileptic treatment.