Introduction: Cerebral palsy treatment is complex and spends time and resources, so find best responders is challenging.

Methods: Cross-sectional study in cohort of hemiplegic cerebral palsy (HCP) treated with BoNT-A. Data obtained from charts and clinical evaluations. All statistical tests considered p<0.05.

Results: Sixty-six patients concluded all evaluations. Level I GMFCS-ER was related with younger age of gait acquisition, higher child education (CE) and better lower extremity muscle strength. Level I MACS was related with higher CE, better initial UPRS and currents Mini-Mental, muscle strength, MVHT, SCAUE, PRS and UPRS. They also had the lower muscle strength reduction during follow-up. Patients with pre natal insult and those with microcephaly, sensory alteration and spatial hemineglect were level II on GMFCS-ER and MACS. Level I CFCS was in regular school and from Curitiba and Metropolitan area. Those with microcephaly were level III and IV CFCS. Level I CFCS was related with higher CE, head circumference, better currents Mini-Mental, MVHT and SCALE. Levels I and II CFCS had gain on UPRS, while III and IV lost. Patients with pre natal insult and astereognosis had worse GMFM-E. GMFM-E>95% patients had younger sit and gait acquisition age, higher CE, better initial UPRS and higher currents head circumference, Mini-Mental, muscle strength, MVHT, SCALE, SCAUE, hand Brunnstrom, PRS, GMFCS-ER, MACS, CFCS and WeeFIM. There was positive correlation among PRS gain and better FMS levels.

Conclusion/Discussion: Children with better initial UPRS, current Mini-Mental and education were bet responders. Patients with pre natal insult and microcephaly had worst results.