Introduction: Boys are three times more likely to be diagnosed with ADHD as compared to girls. Currently , both diagnostic criteria and treatment protocols are derived from predominantly male populations. The purpose of this study was to investigate comorbid conditions and treatment in girls with ADHD.

Methods: Seventeen girls (4-15years) with a DSM-4-TR diagnosis of ADHD were enrolled in this study. Nine women (２０－４８years) who presented ADHD clinic and addressed their problem featured their childhood.

Results: Five of seventeen girls had a family history of ADHD. Nine children suffered from poor self-esteem. Maladaptive behaviors such as self-injury or aggression were exhibited in eight girls. Three girls showed tics Parental preferences limited the use of medication such as Methylphenidate（MPH） or Atomoxetine. Three girls showed significant improvement of the symptom with MPH. A girl with enuresis showed significant improvement of concentration with Vasopressin(Oral) 。

Conclusions: Stimulant medication is frequently avoided in management with ADHD in girls by father, worrying adverse effects. Girls and women with ADHD struggle with negative self- image for long time. Vasopressin（Oral）worked very well in the treatment of a girl with enuresis and ADHD。