Infections of the central nervous system in children are among the most severe and adverse effects on their disease, the first of which are the meningitis. Analyze the etiological structure, epidemiological features of purulent bacterial meningitis among children of Almaty.

The study of 1183 cases of bacterial meningitis confirmed by bacteriological methods of research.

The etiological structure of purulent bacterial meningitis in 28.2% of cases of pneumococcal meningitis represented (13.1±0.9%), staphylococcus (7.6±0.7%) and Haemophilus influenzae (5.4±0.6%) etiology. Pneumococcal meningitis was diagnosed in 155 persons (50,2±2,8%); staphylococcal meningitis in 90 (29,1±2,6%); H. influenzae type«b» 64 (20,7±2,3%). Sick children aged 1 to 6 months (16,8±2,1%), from 7 to 12 months (12,3±1,8%) and from 4 to 6 years old (20,4±2.3%). Children up to 1 month meningitis diagnosed (2,6±0,8%) of cases. Meningitis often diagnosed among boys (64,7±2,7%), is less common in girls (35,3±2,7%).

Pediatric patients with bacterial meningitis, regardless of age and etiology there is a violation of the immune status, reflected in the reduction of CD3+,HLA-DR,CD16+,B-lymphocytes. The most pronounced changes in the immune status were observed at the age of 1-6 years , in terms of etiology with staphylococcal meningitis , characterized by a significant decrease in the level of mature differentiated T-lymphocytes(CD3+), B- lymphocytes, T-killer cells, CD16+. More than half of children with staphylococcal meningitis values ​​of T-lymphocytes and T-helper cells decreased to 50% of normal.