ICNC2018 Abstracts & Symposia Proposals, ICNC 2014

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Optic neuritis in juvenile idiopathic arthritis patient
fernanda castro monti, Daniela Mencaroni Rodrigues Lourenço, Izabel Mantovani Buscatti, Benito Lourenço, José Albino Paz, Clovis Artur Almeida Silva, Umbertina Conti Reed

Last modified: 2014-04-03

Abstract


Optic neuritis (ON) was rarely reported in juvenile idiopathic arthritis (JIA) patients, particularly in those under anti-tumor necrosis factor alpha blockage. However, to our knowledge, the prevalence of ON in JIA population has not been studied. Therefore, 5,793 patients were followed up at our University Hospital and 630 (11%) had JIA. One patient (0.15%) had ON and was reported herein. A 6 year old male was diagnosed with extended oligoarticular JIA, and received naproxen and methotrexate subsequently replaced by leflunomide. At 11 years old, he was diagnosed with aseptic meningitis followed by a partial motor seizure with secondary generalization. Brain magnetic resonance imaging (MRI) and electroencephalogram showed diffuse disorganization of the brain electric activity and leflunomide was suspended. Seven days later, the patient presented acute ocular pain, loss of acuity for color, blurred vision, photophobia, redness and short progressive visual loss in the right eye.  Fundoscopic exam detected unilateral papilledema without retinal exsudates. Orbital MRI suggested right ON. The anti-aquaporin 4 (anti-AQP4) antibody was negative. Pulse therapy with methylprednisolone was administered for five days and subsequently with prednisone, he had clinical and laboratory improvement. In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required.


Keywords


Optic neuritis, juvenile idiopathic arthritis, anti-aquaporin 4 antibody

References


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