ICNC2018 Abstracts & Symposia Proposals, ICNC 2014

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Lisdexanfetamine as a treatment option for narcholepsia
Fernanda Guedes Morgado, Stella Pinto dos Santos, Roseane Beker, Marcella Vieira, Heloisa Pereira

Last modified: 2014-04-03

Abstract


Narcholepsia is a chronic disorder. Excessive daytime somnolence,cataplexia ( the hallmark of the disease is present in 70% of the cases), hypnopompic hallucinations, sleep paralysis and short latency of REM sleep are often present. The impact of narcholepsia on quality of life justifies efforts for early diagnosis and treatment.

Case report
TFA, 14 years old, presented with excessive sleep since the first months of life. Pregress hystory included precocious puberty at age five and ADHD innatentive subtype treated with methylphenidate with a partial response. Polyssonography with múltiple latencies test results disclosed improper sleep onset in Three out of four opportunities, with a mean latency of 5,1 minutes and three REM sleep cicles.
Her medication was progressivelly scalated to a combination of modafinil, methylphenidate and amitriptilina and the response was described as innitially good but worsenning afterwards. She slept during one hour of the first consult, and it was impossible to keep her awake. The EEG, MRI and blood workout were normal.
The medications were changed for Lisdexanfetamine 50 mg/Day and the patient presented very good response in sleep symptoms, return to social life. Depression was diagnosed in subsequent consultations and fluoxetine 20 mg/ Day was added with good response.
Discussion: Lisdexanfetamina is indicated as a treatment option to ADHD but, in this case, it was prescribed as a central nervous system stimulant in order to control the symptoms of narcholepsia and we obtained a very good response. It seems reasonable to include the drug as a treatment option for narcholepsia.

Keywords


narcholepsia; lisdexanfetamina

References


%ALOE, Flávio et al. Diretrizes brasileiras para o diagnóstico de narcolepsia. Rev. Bras. Psiquiatr. [online]. 2010, vol.32, n.3, pp. 294-305. Epub June 25, 2010.

COELHO, Fernando Morgadinho Santos et al. Narcolepsia. Rev. psiquiatr. clín. [online]. 2007, vol.34, n.3, pp. 133-138

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