Levels of Immunoglobulins, Complement and T Lymphocyte Subsets in the Peripheral Blood of Children with Convulsive Diseases and Their Signifiances

Guo Xiangyang, Wang Jiegying, Li Hongyan, Wang Nana, Zhang Xiaoxia, Liu Chunfeng

Dept.of Pediatrics, Shaanxi Provincial People's Hospita,l 256 You Yi West Road 710068 ,Xi'an, Shaanxi Province, China

Background and Aims: The roles of the innate immune system and complement in the development of acute behavioral seizures have been studied in humans, but the roles of them in the central nervous system remains unclear. In light of these, we study the levels and relationship of immunoglobulins(IgG、 IgA、 IgM、IgE), complement（C3、C4） and T lymphocyte subsets（CD3+、CD4+、CD8+、CD4+/CD8+） in the peripheral blood of children with convulsive diseases. Methods：245 children with convulsive diseases were studied as following: obtaining the samples of the peripheral blood after being in hospital. We investigated the changes of IgG、 IgA、 IgM、IgE、 C3、C4 in the peripheral blood with immunoturbidimetry and CD3+、CD4+、CD8+、CD4+/CD8+ in the peripheral blood with flow cytometry.  Results：(1)In children with convulsive diseases ( febrile seizure, epilepsy ) levels of IgG and IgA in the peripheral blood were decreased. Levels of IgG and IgA were difference in children with febrile seizure and epilepsy. Levels of C3 and C4 were increased in children with convulsive diseases and difference in children with febrile seizure and epilepsy. (2) In children with convulsive diseases ( febrile seizure, epilepsy ) levels of CD3+、CD4+ and CD4+/CD8+ in the peripheral blood were decreased and difference in children with febrile seizure and epilepsy. Level of CD8+ was increased in children with convulsive diseases and difference in children with febrile seizure and epilepsy. Conclusion：There are immune dysfunction in children with convulsive diseases. It suggested immune dysfunction is correlated with epileptogenesis.