Aim & Objective: To evaluate the mean serum vitamin B12 levels in children with infantile spasms as compared to children with Global Developmental Delay without infantile spasms aged 6 months to 3 years.

Materials and Methods: Study population consisted of children presenting to the out patient department and pediatric wards of Kalawati Saran Children’s Hospital. Study was conducted from November 2014 to March 2016. Primary Outcome Variable was mean serum vitamin B12 levels in two groups. Secondary Outcome Variable was to find the Percentage of patients with vitamin B12 deficiency defined as level below 160pg/ml in children with infantile spasms.

Results: West syndrome patients had lower mean serum vitamin B12 levels as compared to patients with GDD without spasms. Out of total 40 cases 14 patients had serum vitamin B12 levels <160 pg/ml. Mean serum levels of homocysteine and mean levels of urinary methylmalonic  acid were elevated  in patients of West syndrome as compared to GDD patients and the elevated levels were significant with p value <0.05.

Conclusion: Vitamin B12 deficiency may have an association with infantile spasms. More studies are needed before recommending routine measurement of serum B12 levels in Children with infantile spasms.