Purpose:To discribe clinical features of  MOG-antibody positive pediatric cetral nerve system inflammatory dymyelination

Method:Retrospectively analyze  31 patients diagnosed as central nervous system inflammatory demyelinating diseases with positive serum MOG-antibody between January 2017 and March 2018;.

Result: 31 cases were  included,sex ratio M: F=15: 16.Age of onset ranged from 5 months to 12 years and 2 months old, average age of onset was (7.2±4.4) years old (male 7.7±4.6, female 6.8+±4.4), and no significant difference between genders. 17 cases were  monophasic, including acute disseminated encephalomyelitis 9 cases, optic neuritis 3 cases, clinical isolated syndrome 4 cases ,unknown classification 1case. 14 cases were recurrent. The clinical phenotypes were multiple phasic disseminated encephalomyelitis 5 cases, of multiple sclerosis 4 cases,and 5 cases could not be classified. The most commom presentation of this group in first demyelinating event was fever (15/31), encephalopathy (14/31), and visual loss (12/31) . Brainstem (15/31), basal ganglia (15/31), cerebellum (13/31), cortex (13/31), and subcortical white matter (12/31) were the  most frequent involved in the first demyelination event.Follow up from 2 month to 1.4 year. All except one ADEM case  have no movement disorders, intellectual retardation or visual impairment.

Conclusion: Children's central nervous system inflammatory demyelinating diseases can be mediated by MOG antibodies, cThe majority of the prognosis is good, but the recurrence cases still need further study.