Last modified: 2018-09-09
Abstract
To explore clinical characteristics of children with FCD type II and epilepsy outcomes after surgery.
We retrospectively reviewed 48 cases with definitely pathological diagnoses, age onset ≤18 years old, and follow up ≥ 6 months after the surgery from pediatrics epilepsy center at Peking University First Hospital between 2014 and 2016.
Among 48 patients (male: female=24:24), the mean age of onset was 1.88 years (0-12.47). Seizure frequency was 8.72 times per day (0.03-50). Number of antiepileptic drugs before surgery was 2.64 (1-5). Eighteen (37.50%) had developmental retardation before onset and 13 (27.08%) experienced regression after onset. All patients had focal seizures. V-EEG records captured generalized seizures in 4.16%, epileptic spasms seizures in 27.08%, myoclonic seizures in 12.50%, tonic seizures in 8.33%, secondary generalized tonic-clonic seizures in 4.16%. Epilepsy duration was 3.15 years (0.44-12.19). The mean age of surgery was 5.00 years (0.79-15.79). Tailored cortical resection were performed in 93.75%, hemispherectomy in 6.25%. Twenty-eight (58.33%) resected lesions were located in frontal, 5 (10.42%) in parietal, 2 (4.16%) in temporal, 13 (27.08%) in multiple lobes. The duration of follow-up was 1.81±0.71 years and 85.41% achieved seizure free. There was no difference regarding clinical characteristics between pathological subtypes (IIa: IIb=16:32) and between seizure-free and recurrence group (41:7). According to lesion location (in seizure-free group), types of seizures were significantly different between single-lobe and multiple-lobes group (30:11) (P<0.05).
There was possible relationship between types of seizure and lesion location, which would be useful for better understanding of FCD type II in children.