Last modified: 2018-09-09
Abstract
METHODS: Data on clinical, etiological and treatment response in children diagnosed with OMAS over a period of 2 years (2015-2017) were analyzed.
RESULTS: Total 15 patients (9 girls and 6 boys) were included. Median age of onset was 15 months (range: 3 months – 3.5 years). Time to diagnosis ranged between 10 days to 12 months. Median time lag between onset and treatment was 3 months. Median follow-up period was 2 years (range: 2 months - 6.5 years). Acute ataxia was the preponderant inaugural feature. Neural crest tumors were the most common tumors (n=11). In "No tumor group" (n=4), parainfectious (n=1) and idiopathic (n=3) OMS were identified. All but one patient received immunomodulatory treatment. Complete recovery of OMS symptoms was obtained in 8 (61%) children. 2 patients had relapse of symptoms. There was no correlation between grade of tumor and response to treatment.
CONCLUSION: With early initiation of immunomodulatory treatment in the course of illness better outcome is noted. Idiopathic OMAS has poor outcome.