OBJECTIVES

To identify clinical and etiological profile of children and the characteristics of seizures in them along with therapeutic responses

METHODS

Descriptive study with data collection over 36 months for children who presented with seizure to the specialty Epilepsy clinic. Data was analyzed as per recent 2017 ILAE classification

RESULTS

1258 patients were studied.

Etiological Distribution: group I (generalized) 523 (42 %), group II (focal)  667 (53 %) , group III 68 (5%) (unknown onset).  HIE (30%) and NHBI (14% ), Channelopathy (8 %) and  Post Encephalitis Sequelae (9%) respectively.

Use of AEDs. Group I– single AED in 316 (60% ), two in 184 (35%), three or more in 23 (5%) of patients . Sodium Valproate was widely used followed by Clobazam and Levetiracetam.

Group II – single AED in 204 (31%), two in 263 (39%) and, three or more in 200 (30%) patients. Oxcarbazepine was widely used

Weaning off AEDs – 278 (53%) in group I and 241 (36%) of the patients in group II were weaned off and were seizure free.

178 (34%) in group I and 536 (80%) patients in group II were having Neurodevelomental delay.

CONCLUSION

ILAE classification helps us to decide appropriate therapy, likely outcome and associated Comorbidites. Group I -seizures were mainly treated with single AED, more likely to come off medication and less issues with neurodevelopment. Group II - seizures likely to need Two or more AEDs and have less favorable neuro-developmental outcomes.