Introduction

We reviewed outcome of isolated ventriculomegaly defined as ventricular atrial width ≥ 10.0 mm across the atrium of posterior or anterior horn at any gestation by ultrasound.

Objective

To evaluate neuroimaging and short-term outcome in a cohort of isolated fetal ventriculomegaly.

Methods:

All women with fetal ventriculomegaly on ultrasound (2008 - 2015) were identified from fetal medicine database. Ventriculomegaly was classified as mild 10-(12 mm); moderate (12-15 mm) and severe (> 15 mm) (Wax JR et al. Obstet Gynecol Surv 2003). All medical records were reviewed retrospectively to collect data on antenatal, delivery, postnatal management and follow up.

Results

35 cases had isolated ventriculomegaly (21 mild, 5 moderate, 9 severe). 32 were live births.

18 had fetal MRI (7 mild, 3 moderate, 8 severe). Compared to ultrasound, MRI showed additional findings (absent corpus callosum, dilated 3rd ventricle) in only 7 cases (1 mild, 1 moderate, 5 severe).

30 had 1 year follow up. Of 21 mild cases, 14 resolved in utero & had normal development. Of rest 7 cases, 1 was stillbirth, 2 remained mild, 2 had normal postnatal US/MRI, 1 had external hydrocephalus  & 1 had cerebral palsy.

Postnatal US and/or MRI was abnormal in 12 (3 mild, 3 moderate, 6 severe) out of 23 cases (13 mild, 3 moderate, 7 severe).  All babies with severe ventriculomegaly had delayed development.

Conclusion

Fetal MRI provided additional information in isolated severe ventriculomegaly. Mild isolated fetal ventriculomegaly usually resolved.