Objectives: We aimed to study epidemiological and virological surveillance of enteroviruses in children with neuroinfections in Tashkent, Uzbekistan.

Methods: The virological and bacteriological laboratory of Tashkent Medical Academy Hospital provides a CSF analysis, serum and faeces of children with neuroinfections with different etiology, in order to determine enterovirus antigen by an express method, based on a modification of the complement-fixation.

Results: Long-term monitoring enterovirus causing neuroinfections children in Tashkent revealed shifts strains with the creation of landscape map, highlights the emergence of 5 dominant virus cycles and determine the value of their virulence in epidemic process. The beginning of each cycle was characterized by the emergence of a new dominant virus of low virulence that causes an increased incidence of serous meningitis occurring mainly in the medium and the prevalence of severe enterovirus detection of antigen in the blood of the patient. 2-3 years from the start of a new cycle of increased virulence of the dominant virus enterovirus antigen detection in the cerebrospinal fluid, increased registration of a heavy flow of serous meningitis and the percentage of detection of other clinical entities with nervous system. Currently observed changes in the epidemiological features of serous meningitis offset peak incidence in the autumn and seasonality prolongation until January.