Last modified: 2018-09-09
Abstract
Damage within the central nervous system (CNS) causes a leakage of intracellular enzymes into the cerebrospinal fluid (CSF). The CSF concentrations of lactic dehydrogenase (LDH), creatine phosphokinase (CPK), creatine kinase BB (CK-BB) and aspartataminotransferase (AST) were measured in children with viral meningencephalitis-group (GR):A, with children with viral meaningitis (divided poor prognosis-Gr:B and good prognosis Gr:C) and with meaningismus (Gr:D) on admission and after treatment to establish whether any of those enzymes would correlate with the outcome.
The activity of LDH, CPK and AST was determined by photocolourimetric assay (Labsystem) and CK-BB by ELISA.
Results: Determination of enzymes on admission.
During the treatment the activity of CPK increased from 4.8 to 6.9 in Gr:C and decreased from 6.1 to 2.5 in Gr:B.
Conclusion: A significant rise of LDH and AST activity, low amount of CK-BB and decrease of CPK activity in the CSF during the treatment correlated with poor prognosis in children with CNS infections.