Introduction: There has been an increase in incidental abnormal lesions which show demyelinating features on MRI scans of the brain due to increasing use of MRI. These findings are more prevelant in adulthood, and were defined as “radiologically isolated syndrome” (RIS) in 2009. RIS criteria have not yet been established in the childhood. Although there is limited information related to prognosis, it has been reported in a single study, approximately 40% of the patients developed MS and 60% had a radiological change similar to adult age group. The aim of our study to discuss the clinical and radiological course of patients who have compatible lesions with RIS.

Material-Methods: Sixteen patients were diagnosed with RIS according to the 2010 McDonald criterion. Cranial MR examinations involving T2-, T1-, FLAIR-, and gadolinium sequences were repeated every 6 months or every year, in all patients who followed 1-7 years. New lesion development and gadolinium involvement were assessed. In some cases, CSF oligoclonal band and spinal MR examinations were also performed. New clinical manifestations were followed.

Results: The patients were aged 9-17 years and male / female ratio was equal. One of them was 7 years, 9 of them> 2 years and 6 of them were followed at least 1 year. No new clinical signs or episodes developed in any of the patients.

Conclusion: In childhood there is a need for long-term studies with more patient numbers in order to determine RIS criteria and to provide information about the prognosis.