Modest improvements in IQ in children with epilepsy who underwent epilepsy surgery, a finding which was not seen in children with severe epilepsy who did not undergo surgery. 

To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs.

Results of an observational cohort study examining malformation rates in 1461 pregnancies exposed to AED monotherapy and 484 pregnancies exposed to AED polytherapy over a 15-year period (1999-2014) based on the data for the outcomes of completed pregnancies recorded in the Australian Pregnancy Register from 1999 to the end of 2014 suggests fetal malformation rates have increased in polytherapy pregnancies over time, while rates had fallen in monotherapy pregnancies. Interestingly the increase in fetal malformation rates in polytherapy pregnancies seemed to have started to rise around 2005. This is around the time when the use of levetiracetam and topiramate...

A pathogenic role of immunity in epilepsies has long been suggested based on observations of the efficacy of immune-modulating treatments and, more recently, by the finding of inflammation markers including autoantibodies in individuals with a number of epileptic disorders. Clinical and experimental data suggest that both innate and adaptive immunity may be involved in epilepsy. Innate immunity represents an immediate, nonspecific host response against pathogens via activation of resident brain immune cells and inflammatory mediators. These are hypothesized to contribute to seizures and epileptogenesis. Adaptive immunity employs activation of antigen-specific B and T lymphocytes or antibodies in the context...

Intranasal administration of lorazepam is not found to be inferior to intravenous administration for termination of acute convulsive seizures in children