Classic differentiation between Ohtahara syndrome and early myoclonic epilepsy | ||
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Differentiation between Ohtahara syndrome and early myoclonic epilepsy | ||
Ohtahara Syndrome | Early Myoclonic Encephalopathy | |
EEG pattern | Continuous suppression burst | Discontinuous pattern, suppression burst not always evident at first, and often more distinct during sleep |
Primary seizure type | Tonic spasms | Myoclonus |
Other seizure types | Focal motor seizures Hemiconvulsions Generalized tonic-clonic seizures | Focal motor seizuresTonic spasms |
Major etiology | Structural lesions | Metabolic abnormalities |
Evolution of disease | 75% progress to West syndrome, 12% progress to Lennox-Gastaut syndrome | Up to 50% develop transient atypical hypsarrhythmia, with subsequent return to the suppression burst pattern |
Adapted from: long:23044011