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content:methylphenidate [2024/03/22 21:16] – biju.hameed@gmail.com | content:methylphenidate [2024/03/22 21:25] (current) – [Methylphenidate Preparations] biju.hameed@gmail.com | ||
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====== Methylphenidate Preparations ====== | ====== Methylphenidate Preparations ====== | ||
- | Methylphenidate is available in 2 different isomer formulations. It is essential to know which formulation you are dealing with when converting from 1 stimulant to another. Those conversions are less precise if the new medication has a different formulation of isomers than the old one. | + | Methylphenidate |
* 50% Dex and 50% Levomethylphenidate | * 50% Dex and 50% Levomethylphenidate | ||
* Ritalin, Methylin, Ritalin SR, Methylin ER, Metadate ER,Ritalin LA, Metadate CD, Aptensio XR, Adhansia XR, Concerta, QuilliChew ER, Quillivant XR, Cotempla XR-ODT, Daytrana, Jornay PM, Medikinet | * Ritalin, Methylin, Ritalin SR, Methylin ER, Metadate ER,Ritalin LA, Metadate CD, Aptensio XR, Adhansia XR, Concerta, QuilliChew ER, Quillivant XR, Cotempla XR-ODT, Daytrana, Jornay PM, Medikinet | ||
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| Concerta, Aptensio XR, | | Concerta, Aptensio XR, | ||
| Adhansia XR | 16 | | | Adhansia XR | 16 | | ||
- | | Dexmethylphenidate | + | | Dexmethylphenidate |
| Dexmethylphenidate XR (Focalin XR) | 8-12 | | | Dexmethylphenidate XR (Focalin XR) | 8-12 | | ||
- | * The stimulants also vary in their duration of action, from 3-5 hours with Ritalin to 16 hours with Adhansia and Mydayis. If you are switching to a stimulant with a longer duration of action, you may need to raise the dose because it will be spread out over a longer period of time. | + | * The stimulants also vary in their duration of action, from 3-5 hours with Ritalin to 16 hours with Adhansia and Mydayis. |
+ | * If you are switching to a stimulant with a longer duration of action, you may need to raise the dose because it will be spread out over a longer period of time. | ||
==== Switching to or from stimulants with unique absorptions and bioavailability ==== | ==== Switching to or from stimulants with unique absorptions and bioavailability ==== | ||
such as orally disentegrating ODTs (Adzenys, Cotempla), transdermal Daytrana, or delayed-release Jornay PM | such as orally disentegrating ODTs (Adzenys, Cotempla), transdermal Daytrana, or delayed-release Jornay PM | ||
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| Methylphenidate x0.86 | Methylphenidate x 1.35 | Adderall x 0.63 | | | Methylphenidate x0.86 | Methylphenidate x 1.35 | Adderall x 0.63 | | ||
- | ^ **Concerta** | + | ^ **Concerta** |
- | | 18 mg/ | + | | 18 mg/ |
- | | 27 mg/ | + | | 27 mg/ |
- | | 36 mg/ | + | | 36 mg/ |
- | | 54 mg/ | + | | 54 mg/ |
+ | |||
+ | ==== Isomer Adjustments ==== | ||
+ | |||
+ | * All conversions are approximate, | ||
+ | * For methylphenidate, | ||
+ | ==== Medikinet® retard and Concerta® ==== | ||
Medikinet® retard and Concerta® are two MPH preparations with different release profiles and proved efficacy on ADHD symptoms as well as co-morbid conditions. | Medikinet® retard and Concerta® are two MPH preparations with different release profiles and proved efficacy on ADHD symptoms as well as co-morbid conditions. | ||
- | ==== Medikinet | + | |
+ | **Medikinet** | ||
* Medikinet retard contains equal proportions of IR and slow release MPH. This once-daily extended-release formulation had a duration of action of about 8 hours in an analog classroom setting. | * Medikinet retard contains equal proportions of IR and slow release MPH. This once-daily extended-release formulation had a duration of action of about 8 hours in an analog classroom setting. | ||
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* Medikinet XL may, therefore, be administered either as an intact capsule, or the capsule may be opened and the contents swallowed, without chewing, immediately after sprinkling onto applesauce or other similar soft food. | * Medikinet XL may, therefore, be administered either as an intact capsule, or the capsule may be opened and the contents swallowed, without chewing, immediately after sprinkling onto applesauce or other similar soft food. | ||
- | ==== Concerta | + | **Concerta** |
* The tablet coating of Concerta dissolves within 1 to 2 hours and releases 22% of the total dose of MPH providing an initial maximum drug concentration at about 1 to 2 hours. | * The tablet coating of Concerta dissolves within 1 to 2 hours and releases 22% of the total dose of MPH providing an initial maximum drug concentration at about 1 to 2 hours. |