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Medikinet® retard and Concerta® are two MPH preparations with different release profiles and proved efficacy on ADHD symptoms as well as co-morbid conditions.
- Medikinet retard contains equal proportions of IR and slow release MPH. This once-daily extended-release formulation had a duration of action of about 8 hours in an analog classroom setting, with efficacy corresponding to twice-daily administration of IR MPH.
- The tablet coating of Concerta dissolves within 1 to 2 hours and releases 22% of the total dose of MPH. The remaining 78% of the dose is osmotically controlled (osmotic-release oral system [OROS] technology) and released over 10 hours through a lazer-drilled hole. The maximum effect occurs 6−8 hours after dosing.
https://www.psychiatrictimes.com/view/how-to-switch-stimulants-dosing-guide-for-adhd?slide=12
Discussion