• Medikinet retard contains equal proportions of IR and slow release MPH. This once-daily extended-release formulation had a duration of action of about 8 hours in an analog classroom setting.
• Medikinet XL has a plasma profile showing two phases of active substance release, with a sharp, initial, upward slope similar to a methylphenidate hydrochloride immediate-release tablet, and a second rising portion approximately three hours later, followed by a gradual decline.
• When taken in the morning after breakfast, the immediate-release portion of the hard capsule dissolves rapidly and results in an initial peak plasma concentration. After passing through the stomach and into the small intestine, the sustained-release portion of the hard capsule releases its methylphenidate hydrochloride. This results in the formation of a 3–4-hour plateau phase during which concentrations do not sink below 75% of the peak plasma concentration^[1].
• The amount of methylphenidate hydrochloride absorbed when Medikinet XL is administered once daily is comparable with conventional immediate-release formulations administered twice daily.

• The tablet coating of Concerta dissolves within 1 to 2 hours and releases 22% of the total dose of MPH. The remaining 78% of the dose is osmotically controlled (osmotic-release oral system [OROS] technology) and released over 10 hours through a lazer-drilled hole. The maximum effect occurs 6−8 hours after dosing.

Resources

• https://www.nepho.org/wp-content/uploads/2023/02/ADHD-Medication-Conversion-Chart.pdf
• https://www.psychiatrictimes.com/view/how-to-switch-stimulants-dosing-guide-for-adhd?slide=12