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content:opsoclonus_myoclonus_ataxia_syndrome [2024/03/12 08:56] – biju.hameed@gmail.com | content:opsoclonus_myoclonus_ataxia_syndrome [2024/03/15 19:11] (current) – biju.hameed@gmail.com | ||
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+ | ====== Opsoclonus Myoclonus Ataxia Syndrome ====== | ||
+ | {{page> | ||
^ Recommendations for the Dosing and Monitoring of Immunotherapeutic Agents in the Treatment of OMAS: Steroid Treatment and Ivig || | ^ Recommendations for the Dosing and Monitoring of Immunotherapeutic Agents in the Treatment of OMAS: Steroid Treatment and Ivig || | ||
| **Treatment of OMS in children** | | **Treatment of OMS in children** | ||
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| Regimen | | Regimen | ||
| | Pulsed dexamethasone has been widely used as first-line steroid treatment. This may be given as: | | | | Pulsed dexamethasone has been widely used as first-line steroid treatment. This may be given as: | | ||
- | | | + | | |20 mg/m<sup>2</sup>/day in 2 divided doses on 3 consecutive days (3 d-treatment defined as 1 pulse) |
- | | | + | | |12 pulses at 3 to 4 weekly intervals |
| | The scheduled 12 pulses of dexamethasone should always be completed, even with earlier complete remission. | | | The scheduled 12 pulses of dexamethasone should always be completed, even with earlier complete remission. | ||
| | Additional dexamethasone pulses may be given, or the interval between the scheduled dexamethasone pulses may be shortened | | | Additional dexamethasone pulses may be given, or the interval between the scheduled dexamethasone pulses may be shortened | ||
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| | 75 iu/m2 intramuscularly twice daily for 1 wk, once daily for 1 week, alternate days for 2 wk, and then a gradual wean over 11 mo, but a slower titration from daily to alternate day treatment is often needed. | | | 75 iu/m2 intramuscularly twice daily for 1 wk, once daily for 1 week, alternate days for 2 wk, and then a gradual wean over 11 mo, but a slower titration from daily to alternate day treatment is often needed. | ||
| | **Alternative corticosteroid regimens include: | | | **Alternative corticosteroid regimens include: | ||
- | | | + | | |IV pulse methylprednisolone(30 mg/kg/d for 3-5 d) | |
| | Pulse repeated monthly for 6-12 mo or followed by oral prednisone or prednisolone (starting dose 1-2 mg/ | | | Pulse repeated monthly for 6-12 mo or followed by oral prednisone or prednisolone (starting dose 1-2 mg/ | ||
| | Weaning may be performed over 12 mo, which may be more rapid with steroid-sparing agent. Longer treatment may be needed. | | | Weaning may be performed over 12 mo, which may be more rapid with steroid-sparing agent. Longer treatment may be needed. |