Show pageDiscussionOld revisionsBacklinksCite current pageBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Antiseizure medications interactions ====== <csv> Expected changes in plasma concentrations when an AED is added to a pre-existing regimen,,,,,,,,,,,,,,, AED added,PB,PHT,PRM,ETS,CBZ,VPA,OXC,LTG,GBP,TPM,TGB,LEV,ZNS,VGB,FBM PB,-,PHT ↑↓,NCCP,ETS ↓↓,CBZ ↓↓,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓ PHT,PB ↑,-,PRM ↓ PB ↑,ETS ↓↓,CBZ ↓↓,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓ PRM,NCCP,PHT ↑↓,-,ETS ↓↓,CBZ ↓↓,VPA ↓↓,?,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓ ETS,↔,↔,NE,-,↔,VPA ↓,NE,NE,NE,NE,NE,NE,NE,NE,NE CBZ,↔,PHT I↓,PRM ↓ PB ↑,ETS ↓↓,-,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,NE,FBM ↓↓ VPA,PB ↑↑,PHT ↓*,PB ↑↑,ETS I↓,CBZ-E ↑,-,↔,LTG ↑↑,↔,TPM ↓,EE,↔,↔,NE,↔ OXC,PB ↑,PHT ↑,?,?,CBZ ↓,↔,-,LTG ↓,NE,?,?,NE,?,NE,? LTG,↔,↔,NE,NE,↔,↔,NE,-,NE,NE,NE,↔,↔,NE,NE GBP,↔,↔,NE,NE,↔,↔,NE,NE,-,NE,NE,↔,NE,NE,NE TBP,↔,PHT ↑,↔,NE,↔,VPA ↓,?,?,NE,-,?,NE,?,NE,? TGB,↔,↔,↔,NE,↔,↔,NE,NE,NE,NE,-,NE,NE,NE,NE LEV,↔,↔,↔,NE,↔,↔,NE,↔,↔,NE,NE,-,NE,NE,NE ZNS,↔,↔,NE,NE,CBA ↑↓,↔,?,↔,NE,NE,NE,NE,-,NE,? VGB,PB ↓,PHT ↓,PRM ↓ PB ↓,NE,CBZ ↑,↔,NE,NE,NE,NE,NE,NE,NE,-,NE FBM,PB ↑↑,PHT ↑↑,?,?,CBZ ↓ CBZ-E ↑,VPA ↑↑,↔,↔,NE,?,?,NE,?,↔,- </csv> PB = Phenobarbital; PHT = phenytoin; PRM = Primidone; ETS = Ethosuximide; CBZ = Carbamazepine; VPA = Valproic acid; OXC = Oxcarbazepine; LTG = Lamotrigine GBP = Gabapentin; TPM = Topiramate; TGB = Tiagabine; LEV = Levetiracetam; ZNS = Zonisamide; VGB = Vigabatrin; FBM = felbamate H-OXO = 10-hydroxy-oxcarbazepine(active metabolite of OXC); CBZ-E = Cabamazepine 10,11 epoxide NE = None Expected; * Free (pharmacologically active) concentration may increase; NCCP = not commonly coprescribed; ↔ = No change; ↓ = a minor (or inconsistent) decrease in plasma concentration; ↓↓ = a clinically significant decrease in plasma concentration; ↑ = a minor (or inconsistent) increase in plasma concentration; ↑↑ = a clinically significant increase in plasma concentration. source:<html>Patsalos PN, Perucca E (2003) <a href="https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=12849151">Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.</a> <i>Lancet Neurol</i> 2 (6):347-56. DOI: <a href="http://dx.doi.org/10.1016/s1474-4422(03)00409-5">10.1016/s1474-4422(03)00409-5</a> PMID: <a href="https://pubmed.gov/12849151">12849151</a></html> neurolists/aed_drug_interactions.txt Last modified: 2024/02/20 21:18by administrator@icnapedia.org Log In