Differentiating between Ohtahara syndrome and Early Myoclonic Encephalopathy

Classic differentiation between Ohtahara syndrome and early myoclonic epilepsy
Differentiation between Ohtahara syndrome and early myoclonic epilepsy
	Ohtahara Syndrome	Early Myoclonic Encephalopathy
EEG pattern	Continuous suppression burst	Discontinuous pattern, suppression burst not always evident at first, and often more distinct during sleep
Primary seizure type	Tonic spasms	Myoclonus
Other seizure types	Focal motor seizures Hemiconvulsions Generalized tonic-clonic seizures	Focal motor seizuresTonic spasms
Major etiology	Structural lesions	Metabolic abnormalities
Evolution of disease	75% progress to West syndrome, 12% progress to Lennox-Gastaut syndrome	Up to 50% develop transient atypical hypsarrhythmia, with subsequent return to the suppression burst pattern