ICNC2018 Abstracts & Symposia Proposals, ICNC 2014

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Predictors of Neuropsychiatric Manifestations among children with Dengue infection
Loudella Valdon Calotes-Castillo, Marilyn Tan, Marissa Lukban, Aida Salonga, Benilda Sanchez-Gan, martha Lu-Bolanos

Building: Bourbon Cataratas Convention Centre, Foz do Iguaçu
Room: Iguazu II
Date: 2014-05-06 03:45 PM – 04:00 PM
Last modified: 2014-02-09

Abstract


Introduction: Early recognition and improvement in the understanding of the wide spectrum of manifestations in dengue will provide prompt and appropriate management of cases. This study aimed to determine factors predictive of the development of neuropsychiatric manifestations among children with dengue infection

Methods: All children with laboratory-confirmed (positive NS1 antigen or serum IgM for dengue) dengue admitted at the Pediatrics wards of a tertiary government hospital were enrolled. Age, dengue type and severity, presence of malnutrition, fever severity were analyzed to determine association with the development of neuropsychiatric manifestations such as encephalitis, encephalopathy, psychosis, acute disseminated encephalomyelitis (ADEM) and Guillain-Barre syndrome (GBS).

Results: Eight (13.6%) children, (mean age of 10.5 years, 6 males) with dengue developed neuropsychiatric manifestations, namely: encephalitis (n=3), encephalopathy (n=2), ADEM (n=1), GBS (n=1) and psychosis (n=1). Age, dengue severity and type, malnutrition, and fever severity were not significantly related with these manifestations. Seven had secondary type of dengue. Five were classified as dengue fever and three as dengue hemorrhagic fever III. Seven were malnourished.  Mean WBC count, hematocrit and platelet count were 11±5, 0.37±0.07 and 252±153, respectively. One patient died (12.5%) due to increased intracranial pressure.

Conclusion: In an endemic region, dengue infection should be a foremost differential diagnosis of encephalitis, GBS, ADEM, psychosis and encephalopathy, despite absence of thrombocytopenia and leukopenia. This study did not show significant predictive factors in the development of these neuropsychiatric manifestations.





Keywords


Neuropsychiatric manifestations; Dengue CNS involvement; Neurologic manifestations

References


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