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Lamotrigine is a 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine of the phenyltriazine class. It was first licensed for clinical practice in 1991. Lamotrigine is one of the best newer AEDs, although there are now concerns for its use in women and myoclonic epilepsies.
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Carbamazepine is an iminodibenzyl derivative desig nated chemically as 5H-dibenzo[b,f]azepine- 5-carboxamide. It is structurally related to the tricyclic antidepressants. It was first introduced into clinical practice in 1962, mainly for the treat ment of trigeminal neuralgia prior to becoming the main AED for focal epilepsies.
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Acetazolamide, an heterocyclic sulfonamide, is a carbonic anhydrase-inhibiting drug used predominantly for the treatment of glaucoma.
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Perampanel, a first-in-class, noncompetitive, α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor antagonist recently approved for the adjunctive treatment of partial seizures in patients 12 years of age and older when other antiepileptic medications have failed.
