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Since August 2014 there has been several reports in the US and Canada of children presenting with mostly focal limb weakness following recent respiratory tract infection and associated significant grey matter changes on spinal MRI.
The Centers for Disease Control and Prevention (CDC) is working closely with the Colorado Department of Public Health and Environment (CDPHE) and Children's Hospital Colorado to investigate a cluster of nine pediatric patients hospitalized with acute neurologic illness of undetermined etiology. The CDC have also put out a HAN (Health Alert Network) Advisory with guidance about reporting cases to state and local health departments.
13-year-old Will Cornejo of Lone Tree, Colo., recovers at Rocky Mountain Hospital for Children in Denver from what doctors suspect is enterovirus 68Dr Ann Yeh, University of Toronto says that over the last several weeks, the Hospital for Sick Children, in Toronto, have seen a cluster of children presenting with transverse myelitis with atypical neuroimaging findings involving significant grey matter involvement and in some case brain stem involvement With the risk of limited recovery given the extensive grey matter involvement at the Hospital for Sick Children they have taken an aggressive approach upfront with treatment with steroids and early plasma exchange if steroids are ineffective. They have reported some recovery with this treatment.
It is also not clear whether this could represent an infectious process (similar to polio) or post-infectious process and what the inciting agent might be. The neuroinflammation service at SickKids (Ann Yeh) is available to provide advice on any suspect cases.
Investigations are currently ongoing to find out whether these presentations are linked to the nationwide outbreak of EV-D68 associated with severe respiratory disease currently seen in North America.
View the CDC Official Health Advisory here
CDC Investigates Limb Paralysis in Children After Enterovirus 68 Outbreak (ABC News)
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The 11th Pan Arab Child Neurology Conference (PACNA) in collaboration with 19th Annual Conference of Egyptian Society of Child Neuro-Psychiatry (ESCNP) & International Child Neurology Association (ICNA), African Child Neurology Association ( ACNA ) and Both Saudi Epilepsy Society & Saudi Pediatric Neurology Society and 3rd Alexandria Pediatric Neurology Dept. will be held in Palestine Hotel, Alexandria, Egypt from April 1 - 3, 2015
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The Sudanese Association of Paediatricians in association with the International Child Neurology Association (ICNA), the African Child Neurology Association (ACNA) and the Sudanese Society of Neuroscience is happy to announce the ICNA educational meeting to be held in Khartoum, Sudan from 28-30 January 2015. The meeting will be held under the kind patronage of His Excellency the Khartoum State Minister of Health. The scientific programme comprising of plenary lectures and workshops. A Nile cruise and trip to the pyramids are also planned as part of the social programme.
The International faculty will consist of:
Jo Wilmshurst [South Africa]
Charles Newton [UK & Kenya]
Lieven Lagae [Belgium]
Pratibha Singhi [India]
Robert Rust [USA]
Harry Chugani [USA]
Kirsty Donald [South Africa]
In addition to a host of local speakers including:
Mustafa A. Salih
M. El Hadi El Malik
Khalid Mohmed
Khalid Ibraheem
El Sayed M. Ahmed
El Derdri M. El Amin
OsheikSeidi
Enaam N. Gashei
Maha A. El Seid
EhlamAbed El Rhman
Imad Y. Saad El Din
Ahmed Shouk
Haydar E.Babikir
General Information
DATE: 28th-30th. Jan. 2015
Venue: CORENTHIA HOTEL, KHARTOUM
Language: ENGLISH
Certificate of Attendance: Will be available upon request
Exhibition: The venue will also feature trade exhibitors including pharmaceutical companies
Abstracts and Presentations: A limited no of abracts would be accepted for poster presentations at the conference. Please sent in your abstracts as a word document ( A4, Arial, 12pt) to This email address is being protected from spambots. You need JavaScript enabled to view it. before 01.12.2014. Please include your full contact details in the email
To be sent as word a sword document size A4 with font arial size (12) on this e-mail:
On Line Visa:
To apply for an entry visa to Sudan please contact Dr Ali Arabi at This email address is being protected from spambots. You need JavaScript enabled to view it. for more information regarding visa requirements.
Conference President:
Prof. Eisa O. Elamin FRCP, FRCPCH, DTCH
PROGRAM ORGANIZERS
Ali Arabi
Mohmed O. Swar
Satti A/Raheem
SCIENTIFIC PROGRAM COMMITTEE
Mustafa A. Salih
Haydar E. Babikir
| Before 15/12/2014 | After 15/12/204 | |
| Registration Fee | £80 | £100 |
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The Sudanese Association of Paediatricians in association with the International Child Neurology Association (ICNA), the African Child Neurology Association (ACNA) and the Sudanese Society of Neuroscience is happy to announce the ICNA educational meeting to be held in Khartoum, Sudan from 28-30 January 2015. The meeting will be held under the kind patronage of His Excellency the Khartoum State Minister of Health. The scientific programme comprising of plenary lectures and workshops. A Nile cruise and trip to the pyramids are also planned as part of the social programme.
The International faculty will consist of:
Jo Wilmshurst [South Africa]
Charles Newton [UK & Kenya]
Lieven Lagae [Belgium]
Pratibha Singhi [India]
Robert Rust [USA]
Harry Chugani [USA]
Kirsty Donald [South Africa]
In addition to a host of local speakers including:
Mustafa A. Salih
M. El Hadi El Malik
Khalid Mohmed
Khalid Ibraheem
El Sayed M. Ahmed
El Derdri M. El Amin
OsheikSeidi
Enaam N. Gashei
Maha A. El Seid
EhlamAbed El Rhman
Imad Y. Saad El Din
Ahmed Shouk
Haydar E.Babikir
General Information
DATE: 28th-30th. Jan. 2015
Venue: CORENTHIA HOTEL, KHARTOUM
Language: ENGLISH
Certificate of Attendance: Will be available upon request
Exhibition: The venue will also feature trade exhibitors including pharmaceutical companies
Abstracts and Presentations: A limited no of abracts would be accepted for poster presentations at the conference. Please sent in your abstracts as a word document ( A4, Arial, 12pt) to This email address is being protected from spambots. You need JavaScript enabled to view it. before 01.12.2014. Please include your full contact details in the email
To be sent as word a sword document size A4 with font arial size (12) on this e-mail:
On Line Visa:
To apply for an entry visa to Sudan please contact Dr Ali Arabi at This email address is being protected from spambots. You need JavaScript enabled to view it. for more information regarding visa requirements.
Conference President:
Prof. Eisa O. Elamin FRCP, FRCPCH, DTCH
PROGRAM ORGANIZERS
Ali Arabi
Mohmed O. Swar
Satti A/Raheem
SCIENTIFIC PROGRAM COMMITTEE
Mustafa A. Salih
Haydar E. Babikir
| Before 15/12/2014 | After 15/12/204 | |
| Registration Fee | £80 | £100 |
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High-dose erythropoietin (EPO; a hormone) administered within 42 hours of birth to preterm infants was associated with a reduced risk of brain injury, as indicated by magnetic resonance imaging, according to a study in the August 27 issue of JAMA.
Premature infants are at risk of developing encephalopathy of prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin has been shown to be neuroprotective in experimental and retrospective clinical studies.
Russia Ha-Vinh Leuchter, M.D., of the University Hospital of Geneva, Switzerland, and colleagues conducted a study in which 495 infants (born from 26 weeks to 31 weeks and 6 days of gestation) were randomly assigned to receive recombinant human erythropoietin (n=256) or placebo (n=239) intravenously before 3 hours, at 12 to18 hours, and at 36 to 42 hours after birth. In a nonrandomized subset of 165 of the 495 infants (n=77 erythropoietin; n=88 placebo), brain abnormalities were evaluated on magnetic resonance imaging (MRI) acquired at term-equivalent age.
The researchers found that at term-equivalent age, compared with untreated controls, fewer infants treated with recombinant human erythropoietin had abnormal scores for white matter injury (22 percent vs 36 percent); white matter signal intensity (3 percent vs 11 percent); periventricular white matter loss (18 percent vs 33 percent); and gray matter injury (7 percent vs 19 percent).
These findings will require assessment in a randomized trial designed primarily to assess this outcome as well as investigation of the association with neurodevelopmental outcomes.
'Reference:
Association Between Early Administration of High-Dose Erythropoietin in Preterm Infants and Brain MRI Abnormality at Term-Equivalent Age,' Hüppi et al, JAMA, doi:10.1001/jama.2014.9645, published 27 August 2014, abstract.
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