- Lectures / Webinars
- Prompt use of clinical phenomenology and radiological investigations for evaluation for an underlying etiology in cerebral palsy
Prompt use of clinical phenomenology and radiological investigations for evaluation for an underlying etiology in cerebral palsy
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ICNC2024
Symposia: Hidden Etiology of Cerebral Palsy: Shifting Paradigms In An Era of Molecular Genetics
Prompt use of clinical phenomenology and radiological investigations for evaluation for an underlying etiology in cerebral palsy
Shaheen Akhter
Cerebral palsy (CP) is the most common motor disability in childhood. The prevalence of cerebral palsy (CP) is about 2 to 3.4 cases per 1000 children.The etiology of CP is multifactorial. In most cases, CP is thought to be due to prenatal factors. Genetic causes may be responsible for one-third of all CP cases. Many genetic disorders may present with findings consistent with CP. Some inborn errors of metabolism and other progressive disorders may initially mimic CP.The diagnosis of CP is based on a history of non-progressive abnormal motor development with an examination finding. If there are atypical features in the history or examination, metabolic and genetic studies should be performed. Conventional magnetic resonance imaging (MRI) of the brain is often of great benefit in determining the presence of a brain abnormality that may suggest an etiology and prognosis in children with CP. Seventy to ninety percent of children with CP have abnormalities on MRI. Detection or absence of a brain anomaly in a child with CP may indicate an underlying genetic or metabolic etiology. However, there is currently insufficient evidence conclusively about which studies should be ordered. The purpose of this talk is to highlight the time-honored approach of using examination and clinical history tools to focus on further etiological research with neuroimaging modalities to diagnose the possible underlying genetic etiology in cerebral palsy.
Other Lectures in this symposium
Practical aspects of doing genetic testing in CP - Tests available and when to do which one for efficient diagnosis
Genetic insights into the classification and treatment modalities of the cerebral palsies
In-depth analysis of genetic testing in CP with illustrative case studies and a glimpse at the future anticipated developments