Brain connectivity with EEG and neuroradiologic modalities in developmental epileptic encephalopathy with spike-and-wave activation in sleep

ICNC2024
Symposia: Epilepsy As A Brain Network Disease: Implications For The Clinician

Brain connectivity with EEG and neuroradiologic modalities in developmental epileptic encephalopathy with spike-and-wave activation in sleep
Hasan Tekgul

Developmental epileptic encephalopathy with spike-and-wave activation in sleep (DEE-SWAS) is a spectrum of conditions characterized by various phenotypes of cognitive, linguistic, and behavioral regression associated with spike-and-wave activation in sleep (Tekgul et al. 2016). The first EEG-fMRI study on DEE-SWAS was published by De Tiege et al. (2007). DTI and EEG-fMRI studies in DEE-SWAS patients demonstrate a specific neuronal network of propagation, regardless of etiology or individual area of initial epileptic activity (Siniatchkin et al.,2013). The perisylvian/prefrontal network activation is linked to both activation of thalamocortical network and deactivation of default mode network. Since these networks appear to be important in neuropsychological processes and memory formation during sleep, a possible influence of epileptic spikes on these networks could explain neuropsychological deficits and developmental abnormalities in DEE-SWAS. The models of effective connectivity can be used to study the causal relationships at the neural level from fMRI data such as Dynamic Causal Modelling (Friston et al., 2003). Independent of aetiology and individual area of initial epileptic activity, patients with CSWS were characterized by a consistent specific neuronal network of propagation.

Other Lectures in this symposium:
Neuronal connectivity in Tuberous Sclerosis Complex and related mTORopathies.
Epilepsy as a network disease
Neuronal connectivity in self-limited epilepsy with centrotemporal spikes