Journal Watch

karenskjeiKaren L. Skjei, M.D.
Assistant Professor,
Department of Neurology Co-Director,
Epilepsy Surgery Program Director,
Epilepsy Monitoring Unit,
Norton Children's Hospital

Dr. Karen Skjei is an assistant professor of Neurology and Pediatrics at the University of Louisville. She completed her undergraduate studies at Duke University, and her medical education at the University of California at San Francisco School of Medicine. She completed a residency in Pediatrics and a fellowship in Child and Adolescent Neurology at the Mayo Clinic in Rochester, New York. She completed a fellowship in Neurophysiology and Epilepsy at the Children’s Hospital of Philadelphia. Dr Skjei is currently Editor of the ICNApedia Journal Watch

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May 26, 2017 2476 0
N Engl J Med 2017; 376:2011-2020
 
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April 17, 2017 3936 0
Epilepsia, 58(4):522–530, 2017
The International League Against Epilepsy (ILAE) presents a revised operational clas-sification of seizure types. The purpose of such a revision is to recognize that some sei-zure types can have either a focal or generalized onset, to allow classification when theonset is unobserved, to include some missing seizure types, and to adopt more trans-parent names. Because current knowledge is insufficient to form a scientifically basedclassification, the 2017 Classification is operational (practical) and based on the 1981Classification, extended in 2010. Changes include the following: (1) “partial” becomes“focal”; (2) awareness is used as a classifier of focal seizures; (3) the terms dyscognitive,simple...
 
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April 17, 2017 4178 0
Epilepsia Volume 58, Issue 4 April 2017 Pages 531–542
This companion paper to the introduction of the International League Against Epilepsy (ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset. Any focal seizure can further be optionally...
 
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February 18, 2017 3564 0
Proc Natl Acad Sci U S A. 2017 Feb 6
Zika virus (ZIKV) causes microcephaly, whereas other related pathogenic flaviviruses do not. To reach the fetal brain, a virus must be transported from the maternal to the fetal circulation, which requires crossing of the placental barrier. Studies demonstrate that mammalian cell-derived ZIKV, but not two other globally relevant flaviviruses, efficiently infects fetal endothelial cells, a key component of the placental barrier, because only ZIKV can efficiently use the cell-surface receptor AXL.
 
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February 18, 2017 4739 0
Brain. 2017 Jan 10. pii: aww342
 
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February 18, 2017 3996 0
Neurology. 2017 Jan 24;88(4):395-402
 
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Updated February 18, 2017 5940 0
Lancet Psychiatry 2017; published online Feb 15
 
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Updated June 10, 2016 7994 0
Epilepsia. 2016 Jun 5
Results of an observational cohort study examining malformation rates in 1461 pregnancies exposed to AED monotherapy and 484 pregnancies exposed to AED polytherapy over a 15-year period (1999-2014) based on the data for the outcomes of completed pregnancies recorded in the Australian Pregnancy Register from 1999 to the end of 2014 suggests fetal malformation rates have increased in polytherapy pregnancies over time, while rates had fallen in monotherapy pregnancies. Interestingly the increase in fetal malformation rates in polytherapy pregnancies seemed to have started to rise around 2005. This is around the time when the use of levetiracetam and topiramate...
 
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Updated May 14, 2016 10245 0
JAMA Neurology April 25, 2016.
A retrospective observation study of 15 patients ( median age 21yrs) with Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis suggests that while the diffuse cerebral atrophy can be reversible the cerebellar atrophy is irreversible and associated with a poor clinical outcome. In an accompanying editorial Dr Maarten J. Titulaer writes that progressive cerebellar atrophy is a potential biomarker for less favorable response in patients with anti-NMDAR encephalitis, especially in those admitted to the ICU. In addition, the development of diffuse cerebral atrophy should not be a reason to withhold treatment in patients with anti-NMDAR encephalitis. Overall, the outcome is...
 
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Updated May 12, 2016 11395 0
FEBS Letters
Researchers have developed a quick and simple method for measuring bile acids in biological fluids that can be used to rapidly diagnosis of Niemann-Pick disease type C a severe fat storage disorder that can lead to liver disease in infancy and neurological dysfunction starting in childhood or early adult life.
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