Journal Watch

karenskjeiKaren L. Skjei, M.D.
Assistant Professor,
Department of Neurology Co-Director,
Epilepsy Surgery Program Director,
Epilepsy Monitoring Unit,
Norton Children's Hospital

Dr. Karen Skjei is an assistant professor of Neurology and Pediatrics at the University of Louisville. She completed her undergraduate studies at Duke University, and her medical education at the University of California at San Francisco School of Medicine. She completed a residency in Pediatrics and a fellowship in Child and Adolescent Neurology at the Mayo Clinic in Rochester, New York. She completed a fellowship in Neurophysiology and Epilepsy at the Children’s Hospital of Philadelphia. Dr Skjei is currently Editor of the ICNApedia Journal Watch

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ICNA
ICNA
Updated September 24, 2015 12192 1
Eur J Paediatr Neurol. 2015 Jul 18
In a long term retrospective study on children with refractory Childhood Absence Epilepsy (CAE), published in EJPN, Franzoni and colleagues (Franzoni et al., 2015) report a higher incidence of cognitive impairment in children with longer duration of childhood absence epilepsy indicating the not so benign nature of this condition.
 
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ICNA
ICNA
Updated September 18, 2015 8082 0
Seizure. 2015 Sep;31:49-55
PURPOSE:To analyze the adverse events (AEs) significantly associated with levetiracetam (LEV) therapy through a meta-analysis of all available double-blind, randomized placebo-controlled trials (RCTs), performed in any age, gender, ethnic background and disease. General tolerability and study withdrawals due to AEs associated with LEV treatment were also investigated. In addition, a dose-effect responses relationship for all variables was assessed. METHODS:RCTs were identified searching Medline (PubMed), Embase and Cochrane CENTRAL for the words "Levetiracetam" and "randomized controlled trial", with different search strategies, setting the limits "humans" and "English". Very common and common AEs according to the summary of...
 
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Epileptic Disorders
Epileptic Disorders
Updated September 22, 2014 11808 0
Epilepsies originating from the posterior cortex, namely the parieto-occipital lobes and the occipital border of the temporal lobe, account for the minority of focal epilepsies (Boesebeck et al., 2002), therefore, epilepsy surgery in the posterior cortex has been less extensively examined in the literature, relative to that for temporal or frontal lobe epilepsies. Most studies emphasize the difficulty in delineating the precise localisation of a posterior epileptogenic zone (EZ: the site of origin and of primary propagation of ictal discharges; Bancaud et al., 1970; Kahane et al., 2006) because of rather non-specific clinical seizure patterns (Bancaud,...
 
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The Lancet Neurology
The Lancet Neurology
Updated August 29, 2014 14614 0
Lancet Neurol 13 (8):844-54
The Personal View is published on the 40th anniversary of the Glasgow Coma Scale's introduction in a 1974 Lancet article*. Since this seminal publication, the Glasgow Coma Scale has provided a practical method for bedside assessment of impairment of conscious level, the clinical hallmark of acute brain injury. The paper's lead author is Professor Graham Teasdale, of the University of Glasgow, UK, one of the authors of the original paper introducing the scale. Professor Teasdale and colleagues examine the extent to which the original aspirations of the authors have been fulfilled, address some myths and misapprehensions about the scale,...
 
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Pediatric Neurology
Pediatric Neurology
Updated August 28, 2014 13988 1
Pediatr Neurol. 2014 May 29
BACKGROUND: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is becoming an increasingly recognized cause of encephalopathy in cases previously presumed to be viral encephalitis. Various manifestations of this disease include altered mental status, behavioral changes, seizures, and movement disorders. We have noted three distinct subtypes of this disease which appear to have differential responses to immunotherapies and differences in prognosis.
 
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Dev Med Child Neuro
Dev Med Child Neuro
Updated August 26, 2014 10816 0
Dev Med Child Neurol
Aim The aim of this study was to examine whether vigabatrin treatment had caused visual field defects (VFDs) in children of school age who had received the drug in infancy. Method In total, 35 children (14 males, 21 females; median age 11y, SD 3.4y, range 8–23y) were examined by static Humphrey perimetry, Goldmann kinetic perimetry, or Octopus perimetry. The aetiologies of infantile spasms identified were tuberous sclerosis (n=10), other symptomatic causes (n=3), or cryptogenic (n=22). Results Typical vigabatrin-attributed VFDs were found in 11 out of 32 (34%) children: in one out of 11 children...
 
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Journal Of Paediatrics And Child Health
Journal Of Paediatrics And Child Health
Updated August 26, 2014 10333 0
J Paediatr Child Health. 2014 Jun 22
Encephalitis is a complex neurological syndrome caused by inflammation of the brain that occurs with highest incidence in children. It is challenging to diagnose and manage due to the variety of aetiologies and non-specific clinical presentations. We discuss the recent progress in clinical case definitions; review recent, large, prospective epidemiological studies; and describe aetiologies. We emphasise infectious causes relevant to children in Australasia but also consider emerging immune-mediated syndromes responsive to immune therapies. We identify priorities for future research in children, given the potential for climate change and international travel to influence the emergence of infectious agents in our...
 
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Pediatric Neurology
Pediatric Neurology
Updated August 26, 2014 14399 1
Pediatr Neurol. 2014 Jun 6
BACKGROUND: In spite of high occurrence of migraine headaches in school-age children, there are currently no approved and widely accepted pharmacologic agents for migraine prophylaxis in children. Our previous open-label study in children revealed the efficacy of cinnarizine, a calcium channel blocker, in migraine prophylaxis. A placebo-controlled trial was conducted to demonstrate the efficacy and safety of cinnarizine in the prophylaxis of migraine in children.
 
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Journal Of Nuclear Medicine
Journal Of Nuclear Medicine
Updated August 26, 2014 13625 0
J Nucl Med. 2014 May 5;55(7):1099-110
AIMS: A precise assessment of the drug-resistant epileptic pediatric population for surgical candidacy is often challenging, and to date there are no evidence-based guidelines for presurgical identification of the epileptogenic zone. To evaluate the usefulness of radionuclide imaging techniques for presurgical evaluation of epileptic pediatric patients, we compared the results of video-electroencephalography (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR imaging (SISCOM), and interictal PET with 18F-FDG.
 
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ICNA
ICNA
July 28, 2014 8419 1
Acta Paediatr. 2014 Jul 21
AIMS: There is a need for an objective assessment scoring system to evaluate the effectiveness of prophylactic drugs in paediatric migraine and the aim of this study was to evaluate the Paediatric Migraine Disability Assessment score (PedMIDAS).  
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