Journal Watch

karenskjeiKaren L. Skjei, M.D.
Assistant Professor,
Department of Neurology Co-Director,
Epilepsy Surgery Program Director,
Epilepsy Monitoring Unit,
Norton Children's Hospital

Dr. Karen Skjei is an assistant professor of Neurology and Pediatrics at the University of Louisville. She completed her undergraduate studies at Duke University, and her medical education at the University of California at San Francisco School of Medicine. She completed a residency in Pediatrics and a fellowship in Child and Adolescent Neurology at the Mayo Clinic in Rochester, New York. She completed a fellowship in Neurophysiology and Epilepsy at the Children’s Hospital of Philadelphia. Dr Skjei is currently Editor of the ICNApedia Journal Watch

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Dr Paolo Curatolo
Dr Paolo Curatolo
Updated November 21, 2017 10498 0
Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by the development of hamartomas in several organs. Mutations in the TSC1 and TSC2 tumor suppressor genes determin overactivation of the mammalian target of rapamycin (mTOR) signaling pathway and subsequent abnormalities in numerous cell processes. As a result, mTOR inhibitors such as sirolimus and everolimus have the potential to provide targeted therapy for TSC patients. Everolimus has been recently approved as a pharmacotherapy option for TSC patients with subependymal giant-cell astrocytomas (SEGAs) or renal angiomyolipomas (AMLs). However, clinical evidence suggests that this treatment can benefit other TSC-associated disease...
 
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ICNA
ICNA
Updated November 24, 2012 7588 1
Annals of Neurology
 
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ICNA
ICNA
November 24, 2012 6594 0
Dev Med Child Neurol. 2012 Nov;54(11):977-87. doi: 10.1111/j.1469-8749.2012.04370.x. Epub 2012 Sep 5. Salivary gland botulinum toxin injections for drooling in children with cerebral palsy and neurodevelopmental disability: a systematic review. Rodwell K, Edwards P, Ware RS, Boyd R. Source Queensland Paediatric Rehabilitation Service, The Royal Children's Hospital, Herston, Brisbane; School of Population Health, The University of Queensland, Brisbane; Queensland Cerebral Palsy and Rehabilitation Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Abstract ...
 
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ICNA
ICNA
November 24, 2012 5537 1
Neurology. 2012 Aug 28;79(9):864-70. Epub 2012 Aug 15. The Pediatric Stroke Recurrence and Recovery Questionnaire: validation in a prospective cohort. Lo WD, Ichord RN, Dowling MM, Rafay M, Templeton J, Halperin A, Smith SE, Licht DJ, Moharir M, Askalan R, Deveber G; International Pediatric Stroke Study (IPSS) Investigators. Source Departments of Neurology and Pediatrics, The Ohio State University, Columbus, OH, USA.warren.lo@nationwidechildrens.org
 
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ICNA
ICNA
Updated November 24, 2012 8133 0
Dev Med Child Neurol. 2012 Nov;54(11)
Dev Med Child Neurol. 2012 Nov;54(11):1018-24. doi: 10.1111/j.1469-8749.2012.04404.x. Epub 2012 Aug 27. Septo-optic dysplasia in childhood: the neurological, cognitive and neuro-ophthalmological perspective. Signorini SG, Decio A, Fedeli C, Luparia A, Antonini M, Bertone C, Misefari W, Ruberto G, Bianchi PE, Balottin U. Source Centre of Child Neuro-ophthalmology, Unit of Child Neurology and Psychiatry, C. Mondino National Institute of Neurology, IRCCS, Pavia;  Department of Ophthalmology, IRCCS San Matteo Hospital, Pavia  University of Pavia, Pavia, Italy.
 
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ICNA
ICNA
Updated October 12, 2012 23123 1
Epilepsia 52 Suppl 3 ():5-11
A pathogenic role of immunity in epilepsies has long been suggested based on observations of the efficacy of immune-modulating treatments and, more recently, by the finding of inflammation markers including autoantibodies in individuals with a number of epileptic disorders. Clinical and experimental data suggest that both innate and adaptive immunity may be involved in epilepsy. Innate immunity represents an immediate, nonspecific host response against pathogens via activation of resident brain immune cells and inflammatory mediators. These are hypothesized to contribute to seizures and epileptogenesis. Adaptive immunity employs activation of antigen-specific B and T lymphocytes or antibodies in the context...
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